Both sides remain winless in seven games, but Mainz still sit in seventh with realistic hopes of securing European football.
After five straight losses, Bochum have drawn their last two, but are rooted to the bottom of the table with faint hopes of staying up.
Mainz's prospects for a positive result will be lifted if star man Jonathan Burkardt is fully fit. Burkhardt has scored Mainz's last four goals against Bochum.
Four points from the relegation play-off place, Bochum must win to retain any hope of staying in the top flight.
Mainz have the fourth best defensive record behind the top two and St. Pauli, shipping just 40 goals.
The reverse fixture finished 2-0 in Mainz's favour, and we back M05 to do the double and send Dieter Hecking's side down.